This weekend laughs go head-to-head with romance. Will Ferrell’s latest comedy battles My Big Fat Greek Wedding's Nia Vardalosin in her new romantic getaway. Who will be declared the champion?

Land of the Lost is Will Ferrell’s latest vehicle based on the 1974 TV series of the same name. A disgraced paleontologist, Dr. Rick Marshall (Ferrell), his assistant (Anna Friel) and macho tour guide (Danny McBride) accidently slip through a space-time vortex and find themselves in a strange world filled with dinosaurs, monkey people and reptilian Sleesaks (large, scaly, green humanoids that are a cross between a reptile and an insect). This is the usual comedic routine we see from Ferrell, (Old School, Anchorman, Elf) but it seems to work and keeps audiences entertained. The funny man recently appeared on The Discovery Channel’s Man vs. Wild to promote the film where he ate a reindeer eyeball while in the Arctic with host Bear Grylls.

Downloading Nancy is Johan Renck’s first feature film and stars Maria Bello (Coyote Ugly) and Jason Patric (The Lost Boys, The Alamo). The story follows unhappy wife, Nancy, who hires a man she meets on the Internet (Patric) to kill her. Instead the pair ends up falling in love. This psychotic love story could be crazy enough to work because of its unusual premise. But it also could be viewed as a little creepy and disturbing.

The Hangover hopes to be the next big mega-comedy of 2009. Four friends, Bradley Cooper (He's Just Not That Into You), Ed Helms (The Office), Zach Galifianakis and Justin Bartha (National Treasure) travel to Las Vegas for their friend’s bachelor party, only to wake up the next morning from their drunken debauchery not remembering anything from the previous night. And they have lost the groom, who is getting married in just a few hours. Now the threesome has to piece together the night’s events, which includes a tiger, a mysterious baby in the closet, and a naked Asian man in order to find the groom before the start of the ceremony. Todd Phillips directed the film, who also helmed Road Trip (2000), Old School (2003) and Starsky & Hutch (2004).

In My Life in Ruins Nia Vardalos (My Big Fat Greek Wedding) plays Georgia, who is a Greek American tour guide who is leading a group of assorted misfit tourists around Greece. The group finds themselves in several comedic situations and ultimately helps Georgia find her misplaced “mojo.” The light-hearted romantic comedy also stars: Richard Dreyfuss (The Goodbye Girl), Rachel Dratch (Saturday Night Live), Harland Williams (There’s Something about Mary), Alistair McGowan (The Big Impression) and Alex Georgoulis in his first US film.

—Jessica Delli Santi